An appetite suppressant from Hoodia species.
Phytochemistry. 2007 Oct;68(20):2545-53. Epub 2007 Jul 2.
van Heerden FR, Marthinus Horak R, Maharaj VJ, Vleggaar R, Senabe JV, Gunning PJ.
School of Chemistry, University of KwaZulu-Natal, Private Bag X01, Scottsville 3209, South Africa.
Studies conducted at the Council for Scientific and Industrial Research (CSIR, South Africa) identified extracts from Hoodia species, in particular Hoodia pilifera and Hoodia gordonii, as possessing appetite suppressing properties. Two pregnane glycosides were isolated by fractionation of the dried stems of H. gordonii. Their structures were determined as (removed as irrelevant to the point being made - Dr. E) on the basis of spectroscopic studies and conversion to known compounds. Compounds 1 and 2 were also isolated from H. pilifera. Compound 1 was tested for its appetite suppressant properties in rats by oral gavage at 6.25-50mg/kg and the results showed that all doses resulted in a decrease of food consumption over an eight day period and a body mass decrease when compared to the control sample receiving only the vehicle. In a comparative study against a fenfluramine control sample, compound 1 resulted in a reduction in food intake over the study period, with a concomitant overall decrease in body weight while fenfluramine resulted in a small decrease in food intake, but an increase in body weight (though less than control group) over the same period of time.
Explanation in plain English:
"Fenfluramine is the drug that was part of the banned "Fen-Phen" anti-obesity medication combo (the other drug being phentermine). Fenfluramine is also known as Pondimin. Fenfluramine was withdrawn from the U.S. market in 1997 after reports of heart valve disease and pulmonary hypertension, including a condition known as cardiac fibrosis.
All doses of Hoodia active glycoside (P57) reduced subjects appetite MORE over the eight day study than did fenfluramine. The most interesting finding is that the Hoodia glycosides created an environment where the test subjects decreased their body weight, exactly what consumers of a weight loss product want. The tests subjects that received the fenfluramine actually gained weight, not the desired result.
In my opinion Hoodia is a promising new adjunct to any weight loss program. Data is coming in monthly validating this point and I look forward to one day getting a high potency, standardized version of this herbal supplement." Marcus Ettinger DC, BSc 10/2/07
Question: How does Hoodia work?
Answer: There is a chemical, known as P57, within the herb Hoodia that acts as a potent appetite suppressant. This natural chemical called P57 glycoside sends a false message to an area of the brain called the hypothalamus. The hypothalamus receiving this message now believes that we have enough fuel (food) even though we are not full. Because the brain is satisfied, less food is consumed thus less calories are consumed. Combined with regular exercise, weight loss is bound to be the end result.
Question: How many CAOH® Pure Hoodia capsules do I take?
Answer: The recommended dosage is 2-3 capsules per day, one capsule 30 minutes before each meal with an 8 ounce glass of water.
We are all different. If you do not have a problem with a certain meal of the day, let s say breakfast, than just take Pure Hoodia at lunch and dinner. If you find one meal-time during the day is especially difficult due to cravings, than eat 1 stick of celery when you take your Pure Hoodia. The added fiber also creates a sense of fullness making it easier to cope with the cravings.
Question: What weight loss tips do you give your patients?
Eat breakfast!!! Make a protein shake with some strawberries, blueberries and water or have an egg, some veggies with lean ham.
Eat six-eight small meals a day. This can be as little as 3 ounces of white meat chicken or tuna and a celery stick (veggies). Yea, I know it's boring but it sure beats having a heart attack.
Drink an eight ounce glass of water every 2 hours, starting when you get-up in the morning. If you get-up at 7:00am it would look like this: 7, 9, 11, 1, 3, 5, 7, 9. If you like to drink more than go for it, but spread it out.
Do not eat any form of simple carbohydrate for breakfast or lunch, and keep it to a minimum at dinner too. Examples are: bread, rice, pasta, bagel, fries, jelly, sugar, potato, corn .
Burn more calories than you eat. This is a simple point but the vast majority of us aren't doing it? Before work, at lunch, and after dinner go for a 15 minute walk, it s just 45 minutes a day and it could potentially save your life. At least it will increase your circulation and make you feel more alive!
Add more fiber to your diet. Celery, green leafy vegetables, apples, and psyllium husk (taken with water or added to a shake) are great examples of foods that will help you feel full and aid in weight loss.
Lifting weights will increase the density of your muscles and burn calories. Fat doesn't need to burn calories to survive but muscle does. So the more muscle you have the more calories per day you will burn. Body builders have to consume as much as 8,000 or more calories per day just to maintain their muscle mass. The average person only needs 1,200 but consumes over 2,000; these 800 additional unburned calories turn to fat.
*Convention on International Trade in Endangered Species of wild fauna and flora is an international agreement between governments, drafted as a result of a resolution adopted in 1963 at a meeting of members of the World Conservation Union (IUCN). Its aim is to ensure that international trade in specimens of wild animals and plants does not threaten their survival and it accords varying degrees of protection to more than 33,000 species of animals and plants. It is illegal to export Hoodia gordonii from South Africa without a license and a CITES Certification. We purchase only from licensed growers and exporters that have full certification.
**The San (or Bushmen) were the original inhabitants of South Africa, appearing there about 30 000 years ago, but were displaced westward from the lush mountains in the east toward the dryer Kalahari desert by the more powerful Zulu and Xhosa tribes who came from the north. Only a few scattered bands remain. Together with the Khoikhoi they form the Khoisan group.